Alliance iS HPLC System

Quality control (QC) laboratories face strict, ever-increasing requirements for compliance and data quality in order to release products on tight deadlines and within budget. These challenges are exacerbated by staff turnover and training requirements. To address these challenges, the Alliance iS HPLC system was developed to improve the efficiency of your QC lab by delivering accurate results the first time, reducing analysis time, and minimizing errors along the way.

Benefits

• Increase the productivity and efficiency of your quality control laboratory by reducing human error through hardware and intuitive touchscreen tools that stop erroneous injection cycles before injection even begins; 
• Ensure data integrity and consistency and maximize system uptime through consistent user operations with guided operational tools that ensure proper system preparation;
• Increasing your laboratory’s return on investment (ROI) in equipment and analysts through improved situational awareness and automated system health monitoring, which quickly reports system status and simplifies decision-making;
• reducing unexpected system downtime and shortening the troubleshooting cycle through guided troubleshooting and maintenance, as well as improved component maintenance—all accessible via the instrument’s touchscreen;
• Repeatable global method performance achieved through improved thermal stability, equipment compatibility with legacy methods, and intelligent method transfer tools.
• Reduced sample carryover and improved temperature stability thanks to the latest, historically reliable Waters instrument technologies.

*Information is based on a 2022 Waters market study that surveyed 56 global pharmaceutical QC laboratories using >25 systems.

High-Performance Analytical Detectors

The system is equipped with two analytical detectors—UV and PDA.

Solvent mixing

A four-channel pump ensures precise solvent mixing at pressures up to 10,000 psi and a maximum operating flow rate of up to 10.0 mL/min. The pump is equipped with an integrated degassing system for all four solvent chambers.

Versatile Column Control

Suitable for analytical columns up to 300 mm in length and 8 mm in inner diameter. The column temperature can be maintained within a range of 4 to 90 °C. The eConnect™ Technology tracking system allows you to monitor the usage and history of analytical columns.

Sample Manager

The sample manager uses a “flow-through-needle” (FTN-R) design to aspirate samples and hold them in the needle while preparing the sample for injection into the column. The needle becomes part of the flow path, so the mobile phase flushes the needle during the cycle, ensuring complete sample recovery and minimizing carryover.

The standard configuration supports injection volumes of 0.1–100.0 μL. Additional extension loops can increase the volume up to 2,000 μL. The sample temperature is adjustable from 4° to 40°C.

Learn more about how easy it is to use the Alliance iS HPLC system with the manufacturer’s series of instructional videos